Naomi Armstrong

March  8, 2025

5 Dangerous Side Effects to Watch Out For if You're Taking GLP-1 Medications

Followed by a short quiz to learn more about your experience with GLP-1 and recommended support supplements.

GLP-1 medications like Ozempic, Wegovy, and Mounjaro have quickly become game-changers in the management of type 2 diabetes and weight loss. They work by mimicking a naturally occurring hormone in the body that helps regulate blood sugar levels, slows digestion, and reduces appetite. But while their benefits are well-documented, it's equally important to understand the potential risks that come with long-term use. Many users experience mild side effects like nausea or fatigue, but there are more serious concerns that can be overlooked or dismissed as “just part of the process.”

These aren’t just uncomfortable—they can be dangerous if not addressed early.Whether you’re new to GLP-1s or have been taking them for months, staying informed about potential complications can help you take control of your health and avoid unnecessary setbacks. In this article, we’ll break down the top 5 dangerous side effects associated with GLP-1 medications—what causes them, what symptoms to look out for, and most importantly, what you can do to prevent them. Because the goal isn’t just to get results—it’s to get results safely, sustainably, and with your overall health in mind.

Luckily there are measures you can take to mitigate and eliminate many of these side effects, at the end of this article take the GLP-1 Quiz to find out what supplements can help support your GLP-1 journey.

Top 5 GLP-1 Side Effects

#5 Kidney Function Impairment (Acute Kidney Injury or Dehydration)

Dehydration is a common concern for GLP-1 users, especially early on when nausea, vomiting, and appetite suppression are at their peak. But what starts as mild dehydration can sometimes progress into something more dangerous—acute kidney injury (AKI). Your kidneys require adequate fluid levels to properly filter waste and regulate electrolytes. Without that, you may experience symptoms like fatigue, swelling, changes in urination, or even shortness of breath. Older adults and those with pre-existing kidney conditions are particularly vulnerable. If you’re using a GLP-1, drinking enough water isn't optional—it’s essential. Electrolyte imbalances can worsen the situation, so maintaining mineral balance is also important. Balanced 8 includes hydration-supporting ingredients to help users replenish what they lose and protect kidney health along the way. If you notice signs of kidney stress, don’t wait—talk to your doctor about lab tests to check your kidney function and make adjustments as needed.

# 4 Severe Hypoglycemia (Especially When Combined with Other Medications)

GLP-1 medications alone don’t typically cause dangerously low blood sugar, but when combined with other glucose-lowering drugs like insulin or sulfonylureas, the risk of hypoglycemia increases significantly. Hypoglycemia occurs when blood sugar levels drop too low—typically below 70 mg/dL. Symptoms can range from shakiness, sweating, and irritability to confusion, blurred vision, or even seizures in extreme cases. The challenge is that early signs can be subtle and easy to miss, especially for people new to diabetes medications. If you’re on a combo therapy, it’s essential to monitor your blood sugar levels regularly and understand your personal risk factors. Carrying quick glucose sources like tablets or juice is smart, but prevention is key. Balanced 8 helps support metabolic function without adding to blood sugar drops—allowing you to maintain balance while benefiting from your medication. Always work closely with your doctor to adjust dosages if hypoglycemia becomes a recurring issue.

# 3 Gallbladder Issues (Gallstones or Cholecystitis)

Weight loss—especially rapid weight loss—can increase the risk of developing gallstones. Since GLP-1 medications often cause significant weight reduction in a short period of time, gallbladder complications are a legitimate concern. Gallstones form when bile stored in the gallbladder hardens into small crystals. While some people never experience symptoms, others may deal with sharp pain in the upper right abdomen, nausea after eating fatty meals, or even fever and jaundice—signs of a more serious infection called cholecystitis. GLP-1s can also slow bile release, compounding the issue. If you have a history of gallbladder disease, let your doctor know before starting a GLP-1. Staying well-hydrated, eating balanced meals with healthy fats, and avoiding extreme caloric deficits can support gallbladder function. Some supplements may also help thin bile and prevent stones. Balanced 8 includes key ingredients to support liver and gallbladder health for this very reason.

#2 Pancreatitis (Inflammation of the Pancreas)

Though rare, pancreatitis is a potentially life-threatening side effect that has been reported in some GLP-1 users. It occurs when the pancreas becomes inflamed and begins to digest itself—often suddenly and without warning. Symptoms can include severe abdominal pain that radiates to the back, nausea, vomiting, fever, and a rapid pulse. If not treated immediately, pancreatitis can lead to complications like infection, tissue damage, or long-term organ dysfunction. While the overall risk is low, individuals with a history of pancreatitis or gallbladder disease may be at higher risk. Because GLP-1s impact how digestive enzymes are released, it’s critical to listen to your body and seek help if you notice sudden, sharp abdominal pain. Regular lab monitoring and supporting your pancreas through anti-inflammatory nutrients may help lower this risk. If you ever suspect pancreatitis, stop taking your medication and contact your healthcare provider right away.

#1 Gastroparesis (Delayed Stomach Emptying)

One of the hallmark features of GLP-1 medications is their ability to slow down digestion, helping users feel fuller for longer. But for some, this can go too far, resulting in a condition called gastroparesis—where the stomach takes too long to empty its contents. This can lead to intense nausea, vomiting, bloating, and early satiety. In more serious cases, it can interfere with your ability to absorb nutrients and maintain proper hydration. Left untreated, gastroparesis can drastically impact quality of life and even lead to hospitalization. If you find yourself constantly full, skipping meals not out of discipline but out of discomfort, or experiencing persistent digestive distress, it may be time to reevaluate your treatment plan. Supporting gut motility and using supplements specifically designed to work alongside GLP-1s, like Balanced 8, can help restore balance while still preserving the medication’s benefits.

Take The GLP-1 Quiz!

Based on your answers we'll suggest supplementation that can help you avoid negative side-effects.